GlobeNewsWire
14 Jul 2026, 06:30 UTC · 2h ago
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PMN310 demonstrated a dose-dependent reduction of amyloid-beta oligomers in human cerebrospinal fluid during a Phase 1a trial. — This provides critical first-in-human proof of target engagement, reducing the technical risk for the lead drug candidate.
+0.60ProMIS Neurosciences expects to present blinded six-month interim data from its Phase 1b PRECISE-AD trial in the coming weeks. — Near-term catalyst that will provide the first safety and biomarker trends in actual Alzheimer's patients.
+0.40PMN310 is designed to target toxic oligomers while avoiding amyloid plaques, potentially reducing the risk of ARIA side effects. — If proven, this differentiates the drug from existing plaque-binding therapies by offering a superior safety profile.
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The company reported successful first human evidence of target engagement for its lead Alzheimer's drug candidate PMN310.
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